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Article

Depletion of RAD17 sensitizes pancreatic cancer cells to gemcitabine

1 Jan 2013

Abstract excerpt

Chemotherapy of advanced pancreatic cancer has mainly been gemcitabine-based for the past 15 years, with only limited effect. Recently, combination therapy that also targets checkpoint kinase 1 (CHK1) has become an attractive option. The central role of CHK1 in many DNA-damage response pathways, however, may result in undesired cytotoxicity in normal cells, causing side effects. We were searching for other target...

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Identifiers

PMID: 23687379
DOI: 10.1242/jcs.124768

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