Quantification of the paternal allele bias for new germline mutations in the retinoblastoma gene.

doi:10.1007/s004390050531

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Article

Quantification of the paternal allele bias for new germline mutations in the retinoblastoma gene.

Human genetics - 1 Sept 1997

Dryja T P, Morrow J F, Rapaport J M

Abstract excerpt

New germline mutations in the human retinoblastoma gene are known to arise preferentially on paternally derived chromosomes, but the magnitude of that bias has not been measured. We evaluated 49 cases with a new germline mutation and found that in 40 cases (82%) the mutation arose on the paternal...

Topics

Adult
Alleles
Chromosomes, Human, Pair 13
Fathers
Female
Genes, Retinoblastoma
Germ-Line Mutation
Humans
Male
Paternal Age

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