Article
Quantification of the paternal allele bias for new germline mutations in the retinoblastoma gene.
Human genetics - 1 Sept 1997
Dryja T P, Morrow J F, Rapaport J M
Abstract excerpt
New germline mutations in the human retinoblastoma gene are known to arise preferentially on paternally derived chromosomes, but the magnitude of that bias has not been measured. We evaluated 49 cases with a new germline mutation and found that in 40 cases (82%) the mutation arose on the paternally derived allele. We also evaluated 48 cases likely to have a somatic initial mutation; in this group the initial...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.