Tyrosine kinase mutations in human cancer.

Abstract excerpt

A subset of tyrosine kinases are activated by mutations which contribute to the malignant transformation, growth, and metastasis of human cancers. Mutations change the expression, conformation and/or stability of tyrosine kinases, often leading to constitutive activation of the signaling pathways the kinases regulate. Given that tyrosine kinases are key members of signaling cascades, mutations have multiple...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to ErbB Receptors
• Share to EGFR gene
• Share to Mutation