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Article

FMNL1 promotes proliferation and migration of leukemia cells

25 Jun 2013

Abstract excerpt

The human FMNL1 is expressed predominantly in hematopoietic cells and has been described previously as overexpressed in hematopoietic malignancies. However, it is not known whether FMNL1 contributes to leukemogenesis. Here, we investigate the FMNL1 function using two different human leukemia models: Namalwa and K562 cell lines. FMNL1 depletion reduced cell proliferation and colony formation in both leukemic cell...

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PMID: 23801653
DOI: 10.1189/jlb.0113057

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