Article
K-RasG12D-induced T-cell lymphoblastic lymphoma/leukemias harbor Notch1 mutations and are sensitive to gamma-secretase inhibitors.
Blood - 15 Oct 2008
Kindler Thomas, Cornejo Melanie G, Scholl Claudia, Liu Jianing, Leeman Dena S, Haydu J Erika, Fröhling Stefan, Lee Benjamin H, Gilliland D Gary
Abstract excerpt
To study the impact of oncogenic K-Ras on T-cell leukemia/lymphoma development and progression, we made use of a conditional K-Ras(G12D) murine knockin model, in which oncogenic K-Ras is expressed from its endogenous promoter. Transplantation of whole bone marrow cells that express oncogenic K-Ras into wild-type recipient mice resulted in a highly penetrant, aggressive T-cell leukemia/lymphoma. The lymphoblasts...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.