Identification of a major locus, TNF1, that controls BCG-triggered tumor necrosis factor production by leukocytes in an area hyperendemic for tuberculosis.

doi:10.1093/cid/cit438

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Article

Identification of a major locus, TNF1, that controls BCG-triggered tumor necrosis factor production by leukocytes in an area hyperendemic for tuberculosis.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 Oct 2013

Cobat Aurelie, Hoal Eileen G, Gallant Caroline J, Simkin Leah, Black Gillian F, Stanley Kim, Jaïs Jean-Philippe, Yu Ting-Heng, Boland-Auge Anne, Grange Ghislain, Delacourt Christophe, van Helden Paul, Casanova Jean-Laurent, Abel Laurent, Alcaïs Alexandre, Schurr Erwin

Abstract excerpt

BACKGROUND: Tumor necrosis factor (TNF) is a key immune regulator of tuberculosis resistance, as exemplified by the highly increased risk of tuberculosis disease among individuals receiving TNF-blocker therapy. METHODS: We determined the extent of TNF production after stimulation with BCG or BCG plus interferon gamma (IFN-γ) using a whole blood assay in 392 children belonging to 135 nuclear families from an area...

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PMID: 23800941
DOI: 10.1093/cid/cit438
PMCID: PMC3765013

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