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Article

Evidence for a major gene influence on tumor necrosis factor-alpha expression in tuberculosis: path and segregation analysis.

Human heredity - 1 Jan 2005

Stein Catherine M, Nshuti Lorna, Chiunda Allan B, Boom W Henry, Elston Robert C, Mugerwa Roy D, Iyengar Sudha K, Whalen Christopher C

Abstract excerpt

OBJECTIVE: Tuberculosis (TB) is a growing global public health problem. Several studies suggest a role for host genetics in disease susceptibility, but studies to date have been inconsistent and a comprehensive genetic model has not emerged. A limitation of previous genetic studies is that they only analyzed the binary trait TB, which does not reflect disease heterogeneity. Furthermore, these studies have not...

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PMID: 16224188
DOI: 10.1159/000088913

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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