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Targeting Mycobacterium tuberculosis Tumor Necrosis Factor Alpha-Downregulating Genes for the Development of Antituberculous Vaccines.

mBio - 31 May 2016

Olsen Aaron, Chen Yong, Ji Qingzhou, Zhu Guofeng, De Silva Aruna Dharshan, Vilchèze Catherine, Weisbrod Torin, Li Weimin, Xu Jiayong, Larsen Michelle, Zhang Jinghang, Porcelli Steven A, Jacobs William R, Chan John

Abstract excerpt

UNLABELLED: Tumor necrosis factor alpha (TNF) plays a critical role in the control of Mycobacterium tuberculosis, in part by augmenting T cell responses through promoting macrophage phagolysosomal fusion (thereby optimizing CD4(+) T cell immunity by enhancing antigen presentation) and apoptosis (a process that can lead to cross-priming of CD8(+) T cells). M. tuberculosis can evade antituberculosis (anti-TB)...

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Identifiers

PMID: 27247233
DOI: 10.1128/mBio.01023-15
PMCID: PMC4895118

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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