Article
Linkage and association analysis of candidate genes for TB and TNFalpha cytokine expression: evidence for association with IFNGR1, IL-10, and TNF receptor 1 genes.
Human genetics - 1 Jul 2007
Stein Catherine M, Zalwango Sarah, Chiunda Allan B, Millard Christopher, Leontiev Dmitry V, Horvath Amanda L, Cartier Kevin C, Chervenak Keith, Boom W Henry, Elston Robert C, Mugerwa Roy D, Whalen Christopher C, Iyengar Sudha K
Abstract excerpt
Tuberculosis (TB) is a growing public health threat globally and several studies suggest a role of host genetic susceptibility in increased TB risk. As part of a household contact study in Kampala, Uganda, we have taken a unique approach to the study of genetic susceptibility to TB by developing an intermediate phenotype model for TB susceptibility, analyzing levels of tumor necrosis factor-alpha (TNFalpha) in...
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