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Article

High Level of Pre-Treatment HIV-1 Drug Resistance and Its Association with HLA Class I-Mediated Restriction in the Pumwani Sex Worker Cohort.

Viruses - 28 Jan 2022

Willim Rachel, Shadabi Elnaz, Sampathkumar Raghavan, Li Lin, Balshaw Robert, Kimani Joshua, Plummer Francis A, Luo Ma, Liang Binhua

Abstract excerpt

BACKGROUND: We analyzed the prevalence of pre-antiretroviral therapy (ART) drug resistance mutations (DRMs) in a Kenyan population. We also examined whether host HLA class I genes influence the development of pre-ART DRMs. METHODS: The HIV-1 proviral DNAs were amplified from blood samples of 266 ART-naïve women from the Pumwani Sex Worker cohort of Nairobi, Kenya using a nested PCR method. The amplified HIV...

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Source

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Identifiers

PMID: 35215866
DOI: 10.3390/v14020273
PMCID: PMC8879707

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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