Article
Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma.
Nature genetics - 4 Dec 2011
Guo Guangwu, Gui Yaoting, Gao Shengjie, Tang Aifa, Hu Xueda, Huang Yi, Jia Wenlong, Li Zesong, He Minghui, Sun Liang, Song Pengfei, Sun Xiaojuan, Zhao Xiaokun, Yang Sangming, Liang Chaozhao, Wan Shengqing, Zhou Fangjian, Chen Chao, Zhu Jialou, Li Xianxin, Jian Minghan, Zhou Liang, Ye Rui, Huang Peide, Chen Jing, Jiang Tao, Liu Xiao, Wang Yong, Zou Jing, Jiang Zhimao, Wu Renhua, Wu Song, Fan Fan, Zhang Zhongfu, Liu Lin, Yang Ruilin, Liu Xingwang, Wu Haibo, Yin Weihua, Zhao Xia, Liu Yuchen, Peng Huanhuan, Jiang Binghua, Feng Qingxin, Li Cailing, Xie Jun, Lu Jingxiao, Kristiansen Karsten, Li Yingrui, Zhang Xiuqing, Li Songgang, Wang Jian, Yang Huanming, Cai Zhiming, Wang Jun
Abstract excerpt
We sequenced whole exomes of ten clear cell renal cell carcinomas (ccRCCs) and performed a screen of ∼1,100 genes in 88 additional ccRCCs, from which we discovered 12 previously unidentified genes mutated at elevated frequencies in ccRCC. Notably, we detected frequent mutations in the ubiquitin-mediated proteolysis pathway (UMPP), and alterations in the UMPP were significantly associated with overexpression of...
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