Article
A systematic evaluation of the function of the protein-remodeling factor Hsp104 in [PSI+] prion propagation in S. cerevisiae by comprehensive chromosomal mutations.
Prion - 1 Jan 2000
Takahashi Aiko, Hara Hideyuki, Kurahashi Hiroshi, Nakamura Yoshikazu
Abstract excerpt
The yeast prion [PSI(+)] represents an aggregated state of the translational release factor Sup35 (eRF3) and deprives termination complexes of functional Sup35, resulting in nonsense codon suppression. Protein-remodeling factor Hsp104 is involved in thermotolerance and [PSI(+)] propagation, however the structure-and-function relationship of Hsp104 for [PSI(+)] remains unclear. In this study, we engineered 58...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.