The functional TP53 rs1042522 and MDM4 rs4245739 genetic variants contribute to Non-Hodgkin lymphoma risk.

doi:10.1371/journal.pone.0107047

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

The functional TP53 rs1042522 and MDM4 rs4245739 genetic variants contribute to Non-Hodgkin lymphoma risk.

PloS one - 1 Jan 2014

Fan Chuanbo, Wei Jinyu, Yuan Chenglu, Wang Xin, Jiang Chuanwu, Zhou Changchun, Yang Ming

Abstract excerpt

As a heterogeneous kind of malignances, Non-Hodgkin lymphoma (NHL) is the most common hematologic cancer worldwide with the significantly increased morbidity in China. Accumulated evidences demonstrated that oncoprotein MDM4 plays a crucial role in the TP53 tumor suppressor signaling pathway. An rs4245739 A>C polymorphism locating in the MDM4 3'-untranslated region creates a miR-191 target site and results in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Asian People

Share to Case-Control Studies

Share to Genes, p53

Share to Lymphoma, Non-Hodgkin

Share to Risk

Share to Risk Factors

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 25203442
DOI: 10.1371/journal.pone.0107047
PMCID: PMC4159297

Genes

MDM4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The functional TP53 rs1042522 and MDM4 rs4245739 genetic variants contribute to Non-Hodgkin lymphoma risk.PMID 25203442Read ↗

Functional MDM4 rs4245739 genetic variant, alone and in combination with P53 Arg72Pro polymorphism, contributes to breast cancer susceptibility.Semantic proximity Read ↗

Association between germline pathogenic variants in cancer-predisposing genes and lymphoma risk.Semantic proximity Read ↗

TP53 mutation predicts the poor prognosis of non-Hodgkin lymphomas: Evidence from a meta-analysis.Semantic proximity Read ↗

Risk of genome-wide association study-identified genetic variants for non-Hodgkin lymphoma in a Chinese population.Semantic proximity Read ↗

MDM4 rs4245739 A > C polymorphism correlates with reduced overall cancer risk in a meta-analysis of 69477 subjects.Semantic proximity Read ↗

No association between MTR rs1805087 A > G polymorphism and non-Hodgkin lymphoma susceptibility: evidence from 11 486 subjects.Semantic proximity Read ↗

LEP and LEPR polymorphisms in non-Hodgkin lymphoma risk: a systematic review and pooled analysis.Semantic proximity Read ↗

Tumor necrosis factor-α induced protein 8 polymorphism and risk of non-Hodgkin's lymphoma in a Chinese population: a case-control study.Semantic proximity Read ↗

Analysis of the Association between MDM4 rs4245739 Single Nucleotide Polymorphism and Breast Cancer Susceptibility.Semantic proximity Read ↗

Evaluation of Genetic Polymorphisms of HOTTIP (rs5883064, rs1859168, rs2067087) in Patients with Non-Hodgkin Lymphoma and Comparison with Healthy Subjects.Semantic proximity Read ↗

Polymorphisms of p53 Arg72Pro, p73 G4C14-to-A4T14 at exon 2 and p21 Ser31Arg and the risk of non-Hodgkin's lymphoma in Japanese.Semantic proximity Read ↗

Germline variation in the 3'-untranslated region of the POU2AF1 gene is associated with susceptibility to lymphoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.