Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Discovery of colorectal cancer PIK3CA mutation as potential predictive biomarker: power and promise of molecular pathological epidemiology.

Oncogene - 5 Jun 2014

Ogino S, Lochhead P, Giovannucci E, Meyerhardt J A, Fuchs C S, Chan A T

Abstract excerpt

Regular use of aspirin reduces incidence and mortality of various cancers, including colorectal cancer. Anticancer effect of aspirin represents one of the 'Provocative Questions' in cancer research. Experimental and clinical studies support a carcinogenic role for PTGS2 (cyclooxygenase-2), which is an important enzymatic mediator of inflammation, and a target of aspirin. Recent 'molecular pathological...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents
Share to Aspirin
Share to Biomarkers, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Class I Phosphatidylinositol 3-Kinases

Share to Colorectal Neoplasms

Share to Molecular Epidemiology

Share to Phosphatidylinositol 3-Kinases

Share to Translational Research, Biomedical

Source

Open in PubMed Open full text

Identifiers

PMID: 23792451
DOI: 10.1038/onc.2013.244
PMCID: PMC3818472

Genes

BRAF
KRAS
MLH1
PTGS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Discovery of colorectal cancer PIK3CA mutation as potential predictive biomarker: power and promise of molecular pathological epidemiology.PMID 23792451Read ↗

Integration of pharmacology, molecular pathology, and population data science to support precision gastrointestinal oncologySemantic proximity Read ↗

Molecular pathological epidemiology of colorectal neoplasia: an emerging transdisciplinary and interdisciplinary field.Semantic proximity Read ↗

The Landscape of PIK3CA Mutations in Colorectal Cancer.Semantic proximity Read ↗

Potential biomarker for aspirin use in colorectal cancer therapy.Semantic proximity Read ↗

Proteogenomic and observational evidence implicate ANGPTL4 as a potential therapeutic target for colorectal cancer preventionSemantic proximity Read ↗

The role of PIK3CA gene mutations in colorectal cancer and the selection of treatment strategiesSemantic proximity Read ↗

Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival.Semantic proximity Read ↗

A New Comprehensive Colorectal Cancer Risk Prediction Model Incorporating Family History, Personal Characteristics, and Environmental Factors.Semantic proximity Read ↗

Genetic analysis of key players in PI3K signaling cascade of colorectal carcinoma.Semantic proximity Read ↗

Aspirin sensitivity of PIK3CA-mutated Colorectal Cancer: potential mechanisms revisited.Semantic proximity Read ↗

Comprehensive Analysis of PIK3CA Mutations in Advanced Colorectal Cancer Using Circulating Tumor DNA ProfilingSemantic proximity Read ↗

Artificial Intelligence-Guided Molecular Determinants of PI3K Pathway Alterations in Early-Onset Colorectal Cancer Among High-Risk Groups Receiving FOLFOXSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.