Article
Directed phenotype switching as an effective antimelanoma strategy.
Cancer cell - 8 Jul 2013
Sáez-Ayala Magalí, Montenegro María F, Sánchez-Del-Campo Luis, Fernández-Pérez María Piedad, Chazarra Soledad, Freter Rasmus, Middleton Mark, Piñero-Madrona Antonio, Cabezas-Herrera Juan, Goding Colin R, Rodríguez-López José Neptuno
Abstract excerpt
Therapeutic resistance in melanoma and other cancers arises via irreversible genetic, and dynamic phenotypic, heterogeneity. Here, we use directed phenotype switching in melanoma to sensitize melanoma cells to lineage-specific therapy. We show that methotrexate (MTX) induces microphthalmia-associated transcription factor (MITF) expression to inhibit invasiveness and promote differentiation-associated expression...
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