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Article

DNA melting analysis for detection of single nucleotide polymorphisms.

Clinical chemistry - 1 Apr 2001

Lipsky R H, Mazzanti C M, Rudolph J G, Xu K, Vyas G, Bozak D, Radel M Q, Goldman D

Abstract excerpt

BACKGROUND: Several methods for detection of single nucleotide polymorphisms (SNPs; e.g., denaturing gradient gel electrophoresis and denaturing HPLC) are indirectly based on the principle of differential melting of heteroduplex DNA. We present a method for detecting SNPs that is directly based on this principle. METHODS: We used a double-stranded DNA-specific fluorescent dye, SYBR Green I (SYBR) in an efficient...

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PMID: 11274012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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