Article
Dysregulation of interferon regulatory factors impairs the expression of immunostimulatory molecules in hepatitis C virus genotype 1-infected hepatocytes.
Gut - 1 Apr 2014
Larrea Esther, Riezu-Boj Jose-I, Aldabe Rafael, Guembe Laura, Echeverria Itziar, Balasiddaiah Anangi, Gastaminza Pablo, Civeira María Pilar, Sarobe Pablo, Prieto Jesus
Abstract excerpt
BACKGROUND: IL-7 and IL-15 are produced by hepatocytes and are critical for the expansion and function of CD8 T cells. IL-15 needs to be presented by IL-15Rα for efficient stimulation of CD8 T cells. METHODS: We analysed the hepatic levels of IL-7, IL-15, IL-15Rα and interferon regulatory factors (IRF) in patients with chronic hepatitis C (CHC) (78% genotype 1) and the role of IRF1 and IRF2 on IL-7 and IL-15Rα...
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