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Article

Hepatitis C virus escape from the interferon regulatory factor 3 pathway by a passive and active evasion strategy

1 Aug 2007

Abstract excerpt

UNLABELLED: Hepatitis C virus (HCV) has been known to replicate with extremely varying efficiencies in different host cells, even within different populations of a single human hepatoma cell line, termed Huh-7. Several reports have implicated the retinoic-acid inducible gene I (RIG-I)/ interferon regulatory factor 3 (IRF-3) pathway of the innate antiviral response with differences in host cell permissiveness to...

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PMID: 17668876
DOI: 10.1002/hep.21829

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