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Article

Innate immune tolerance and the role of kupffer cells in differential responses to interferon therapy among patients with HCV genotype 1 infection.

Gastroenterology - 1 Feb 2013

Lau Daryl T-Y, Negash Amina, Chen Jie, Crochet Nanette, Sinha Mala, Zhang Yuhong, Guedj Jeremie, Holder Sharon, Saito Takeshi, Lemon Stanley M, Luxon Bruce A, Perelson Alan S, Gale Michael

Abstract excerpt

BACKGROUND & AIMS: In patients with hepatitis C virus (HCV) infection, interferon alfa (IFN-α) alters expression of IFN-stimulated genes (ISGs), but little is understood about factors that determine outcomes of therapy. We used a systems biology approach to evaluate the acute response of patients with chronic hepatitis C to IFN-α therapy. METHODS: We collected liver biopsy samples from 8 treatment-naïve patients...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23123437
DOI: 10.1053/j.gastro.2012.10.044
PMCID: PMC3822610

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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