Article
Hedgehog signaling regulates hypoxia induced epithelial to mesenchymal transition and invasion in pancreatic cancer cells via a ligand-independent manner.
Molecular cancer - 20 Jun 2013
Lei Jianjun, Ma Jiguang, Ma Qingyong, Li Xuqi, Liu Han, Xu Qinhong, Duan Wanxing, Sun Qing, Xu Jun, Wu Zheng, Wu Erxi
Abstract excerpt
BACKGROUND: Hypoxia plays a vital role in cancer epithelial to mesenchymal transition (EMT) and invasion. However, it is not quite clear how hypoxia may contribute to these events. Here we investigate the role of Hedgehog (Hh) signaling in hypoxia induced pancreatic cancer EMT and invasion. METHODS: Pancreatic cancer cells were cultured under controlled hypoxia conditions (3% O2) or normoxic conditions. HIF-1α...
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