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Article

Effects of the HIF-1α and NF-κB loop on epithelial-mesenchymal transition and chemoresistance induced by hypoxia in pancreatic cancer cells.

Oncology reports - 1 Apr 2014

Cheng Zhuo-Xin, Wang Da-Wei, Liu Tao, Liu Wei-Xin, Xia Wei-Bin, Xu Jian, Zhang Ying-Hai, Qu Yi-Kun, Guo Lin-Qi, Ding Long, Hou Jie, Zhong Zhao-Hua

Abstract excerpt

Hypoxia is a microenvironmental factor which plays a critical role in tumor development and chemoresistance. Epithelial-to-mesenchymal transition (EMT) induced by hypoxia is one of the critical causes of treatment failure and chemoresistance in different types of human cancers. Stabilization of the hypoxia-inducible factor-1α (HIF-1α) transcription complex, caused by intratumoral hypoxia, promotes tumor...

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Identifiers

PMID: 24535079
DOI: 10.3892/or.2014.3022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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