Article
Structural modeling and in silico analysis of human superoxide dismutase 2.
PloS one - 1 Jan 2013
de Carvalho Mariana Dias Castela, De Mesquita Joelma Freire
Abstract excerpt
Aging in the world population has increased every year. Superoxide dismutase 2 (Mn-SOD or SOD2) protects against oxidative stress, a main factor influencing cellular longevity. Polymorphisms in SOD2 have been associated with the development of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, as well as psychiatric disorders, such as schizophrenia, depression and bipolar disorder. In this...
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