Article

In silico Evaluation of Deleterious nsSNPs in SOD1 and TARDBP Genes Associated with Amyotrophic Lateral Sclerosis

2026-03-25

Abstract excerpt

<title>Abstract</title> <p> Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder involving mutations in the <italic>SOD1</italic> and <italic>TARDBP</italic> genes that significantly influence its development. Nonsynonymous SNPs in these genes can disrupt protein stability, folding, and regulatory functions, leading to motor neuron loss. This study performed an in-silico approach t...

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Literature Corpus work: 2c7a6057-5138-59d6-9e61-bb3e83e154b7
DOI: 10.21203/rs.3.rs-8978267/v1

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