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In silico analysis and molecular dynamics simulation of human superoxide dismutase 3 (SOD3) genetic variants

11 Sept 2018

Abstract excerpt

Oxidative stress is a major factor in aging processes. Superoxide dismutase 3 (SOD3) plays a key role in the protection of extracellular oxidative stress. Missense mutations in SOD3 have been described to be associated with the occurrence of pulmonary, cardiovascular, and neoplastic diseases. This study aims to analyze the effects of missense mutations on the SOD3 structure and function by modeling a complete...

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PMID: 30206983
DOI: 10.1002/jcb.27636

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