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Article

Evolutionary Analyses of Sequence and Structure Space Unravel the Structural Facets of SOD1.

Biomolecules - 4 Dec 2019

Chowdhury Sourav, Sanyal Dwipanjan, Sen Sagnik, Uversky Vladimir N, Maulik Ujjwal, Chattopadhyay Krishnananda

Abstract excerpt

Superoxide dismutase (SOD) is the primary enzyme of the cellular antioxidant defense cascade. Misfolding, concomitant oligomerization, and higher order aggregation of human cytosolic SOD are linked to amyotrophic lateral sclerosis (ALS). Although, with two metal ion cofactors SOD1 is extremely robust, the de-metallated apo form is intrinsically disordered. Since the rise of oxygen-based metabolism and antioxidant...

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Identifiers

PMID: 31817166
DOI: 10.3390/biom9120826
PMCID: PMC6995586

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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