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Article

Does conserved domain SOD1 mutation has any role in ALS severity and therapeutic outcome?

BMC neuroscience - 9 Oct 2020

Pal Surinder, Tiwari Abha, Sharma Kaushal, Sharma Suresh Kumar

Abstract excerpt

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative fatal disease that can affect the neurons of brain and spinal cord. ALS genetics has identified various genes to be associated with disease pathology. Oxidative stress induced bunina and lewy bodies formation can be regulated through the action of SOD1 protein. Hence, in the present study we aim to analyse the structural and...

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Identifiers

PMID: 33036560
DOI: 10.1186/s12868-020-00591-3
PMCID: PMC7547430

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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