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Article

Structural and functional analysis of human SOD1 in amyotrophic lateral sclerosis.

PloS one - 1 Jan 2013

Moreira Lorenna Giannini Alves, Pereira Livia Costa, Drummond Priscila Ramalho, De Mesquita Joelma Freire

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with familial inheritance (fALS) in 5% to 10% of cases; 25% of those are caused by mutations in the superoxide dismutase 1 (SOD1) protein. More than 100 mutations in the SOD1 gene have been associated with fALS, altering the geometry of the active site, protein folding and the interaction between monomers. We performed a functional analysis...

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Source

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Identifiers

PMID: 24312616
DOI: 10.1371/journal.pone.0081979
PMCID: PMC3846731

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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