Article
Nucleosomes shape DNA polymorphism and divergence.
PLoS genetics - 1 Jul 2014
Langley Sasha A, Karpen Gary H, Langley Charles H
Abstract excerpt
An estimated 80% of genomic DNA in eukaryotes is packaged as nucleosomes, which, together with the remaining interstitial linker regions, generate higher order chromatin structures [1]. Nucleosome sequences isolated from diverse organisms exhibit ∼10 bp periodic variations in AA, TT and GC dinucleotide frequencies. These sequence elements generate intrinsically curved DNA and help establish the histone-DNA...
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