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Article

Decreased DNA-PK activity in human cancer cells exhibiting hypersensitivity to low-dose irradiation

1 Aug 2000

Abstract excerpt

Low-dose hyper-radiosensitivity (HRS) (below 0.5 Gy) has been extensively documented in the past few years. The molecular basis of this phenomenon remains largely unknown and the purpose of this study was to investigate the possible implication of the DNA repair DNA-PK complex. The activity of the DNA-PK complex, i.e. Ku DNA-end binding activity and kinase activity of the whole complex, was studied in 10 human...

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PMID: 10945500
DOI: 10.1054/bjoc.2000.1258

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