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RNA Polymerase II Blockage by Cisplatin-damaged DNA

7 Nov 2005

Abstract excerpt

The consequences of human RNA polymerase II (pol II) arrest at the site of DNA damaged by cisplatin were studied in whole cells and cell extracts, with a particular focus on the stability of stalled pol II and its subsequent ubiquitylation. Site-specifically platinated DNA templates immobilized on a solid support were used to perform in vitro transcription in HeLa nuclear extracts. RNA elongation was completely...

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PMID: 16275646
DOI: 10.1074/jbc.m509688200

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