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Low expression of PCK2 in breast tumors contributes to better prognosis by inducing senescence of cancer cells

17 May 2022

Abstract excerpt

Cell cycle arrest, one of the main characteristics of cellular senescence, has been described as a crucial barrier that needs to be bypassed for cancer progression. Typically, cellular senescence can be induced by multiple stresses including telomere shortening, oncogenic activation as well as therapy treatment, and contributes to the inhibition of epithelial-mesenchymal transition (EMT), tumor suppression or...

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PMID: 35580079
DOI: 10.1002/iub.2651

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