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Article

Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition.

Molecular biology of the cell - 1 Sept 2015

Sadaie Mahito, Dillon Christian, Narita Masako, Narita Masashi, Young Andrew R J, Cairney Claire J, Godwin Lauren S, Torrance Christopher J, Bennett Dorothy C, Keith W Nicol, Narita Masashi

Abstract excerpt

Cellular senescence is a widespread stress response and is widely considered to be an alternative cancer therapeutic goal. Unlike apoptosis, senescence is composed of a diverse set of subphenotypes, depending on which of its associated effector programs are engaged. Here we establish a simple and sensitive cell-based prosenescence screen with detailed validation assays. We characterize the screen using a focused...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26133385
DOI: 10.1091/mbc.E15-01-0003
PMCID: PMC4551313

Genes

AURKB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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