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Article

hERG1/Kv11.1 activation stimulates transcription of p21waf/cip in breast cancer cells via a calcineurin-dependent mechanism.

Oncotarget - 13 Sept 2016

Perez-Neut Mathew, Rao Vidhya R, Gentile Saverio

Abstract excerpt

The function of Kv11.1 is emerging in breast cancer biology, as a growing body of evidence indicates that the hERG1/Kv11.1 potassium channel is aberrantly expressed in several cancer types including breast cancers.The biological effects of Kv11.1 channel blockers and their associated side effects are very well known but the potential use of Kv11.1 activators as an anticancer strategy are still unexplored. In our...

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Identifiers

PMID: 25945833
DOI: 10.18632/oncotarget.3797
PMCID: PMC5312283

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