Article
Clinical utility of KRAS and BRAF mutations in a cohort of patients with colorectal neoplasms submitted for microsatellite instability testing.
Clinical colorectal cancer - 1 Sept 2013
Cushman-Vokoun Allison M, Stover Daniel G, Zhao Zhiguo, Koehler Elizabeth A, Berlin Jordan D, Vnencak-Jones Cindy L
Abstract excerpt
BACKGROUND: Molecular analysis has become important in colorectal carcinoma (CRC) evaluation. Alterations in KRAS, BRAF, or mismatch repair (MMR) genes may determine therapeutic response or define a hereditary cancer syndrome. Correlation of DNA studies with clinical findings will further clarify the clinical utility of these markers. PATIENTS AND METHODS: A retrospective study was performed on 111...
Topics
- Adult
- Biomarkers, Tumor
- Colorectal Neoplasms
- Female
- Follow-Up Studies
- Humans
- Male
- Microsatellite Instability
- Middle Aged
- Mutation
- Neoplasm Staging