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Article

Clinical impact of microsatellite instability in colon cancer following adjuvant FOLFOX therapy.

Cancer chemotherapy and pharmacology - 1 Sept 2010

Kim Seung Tae, Lee Jeeyun, Park Se Hoon, Park Joon Oh, Lim Ho Yeong, Kang Won Ki, Kim Jin Yong, Kim Young Ho, Chang Dong Kyung, Rhee Poong-Lyul, Kim Dae Shick, Yun Haeran, Cho Yong Beom, Kim Hee Cheol, Yun Seong Hyeon, Lee Woo Yong, Chun Ho-Kyung, Park Young Suk

Abstract excerpt

PURPOSE: Colon cancer with DNA mismatch repair (MMR) defects reveals indistinguishable clinical and pathologic aspects, including better prognosis and reduced response to 5-fluorouracil (5-FU)-based chemotherapy. There has been no consensus for p53 as a prognostic marker in colorectal cancer. This study investigated the clinical implication of MSI-H/MMR-D and p53 expression in R0-resected colon cancer patients...

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Topics

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Share to Chemotherapy, Adjuvant
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Combined Modality Therapy

Share to DNA Mismatch Repair

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Source

Identifiers

PMID: 20033812
DOI: 10.1007/s00280-009-1206-3

Genes

MLH1
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Clinical impact of microsatellite instability in colon cancer following adjuvant FOLFOX therapy.PMID 20033812Read ↗

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Determination of <i>TP53</i> Mutation Is More Relevant Than Microsatellite Instability Status for the Prediction of Disease-Free Survival in Adjuvant-Treated Stage III Colon Cancer PatientsSemantic proximity Read ↗

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