Article
Clinical implications of microsatellite instability in colorectal cancers.
Cancer - 15 Jan 1996
Muta H, Noguchi M, Perucho M, Ushio K, Sugihara K, Ochiai A, Nawata H, Hirohashi S
Abstract excerpt
BACKGROUND: Microsatellite instability (MI) has been reported in some sporadic colon tumors and in cases of hereditary nonpolyposis colorectal cancer (HNPCC). The criteria for HNPCC have not been fully defined, and clinical criteria are used to identify as many HNPCC patients as possible. To clar...
Topics
- Age of Onset
- Colorectal Neoplasms, Hereditary Nonpolyposis
- DNA, Neoplasm
- Genetic Markers
- Humans
- Microsatellite Repeats
- Middle Aged
- Mutation
- Neoplasms, Multiple Primary
- Tumor Suppressor Protein p53