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Article

MICA and MICB genes: can the enigma of their polymorphism be resolved?

Trends in immunology - 1 Jul 2001

Stephens H A

Abstract excerpt

The human MHC class I chain-related genes (MICA and MICB) are located within the HLA class I region of chromosome 6. Their organization, expression and products differ considerably from classical HLA class I genes. MIC proteins are considered to be markers of "stress" in the epithelia, and act as ligands for cells expressing a common activatory natural killer-cell receptor (NKG2D). Molecular models are now...

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Topics

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Share to Epithelial Cells
Share to Genetics, Population
Share to Histocompatibility Antigens Class I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Killer Cells, Natural

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Share to NK Cell Lectin-Like Receptor Subfamily K

Share to Receptors, Immunologic

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Source

Identifiers

PMID: 11429322
DOI: 10.1016/s1471-4906(01)01960-3

Genes

MICA
MICB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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