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Major Histocompatibility Complex Class I-Related Chain A (MICA) Allelic Variants Associate With Susceptibility and Prognosis of Gastric Cancer.

Frontiers in immunology - 1 Jan 2021

Toledo-Stuardo Karen, Ribeiro Carolina H, Canals Andrea, Morales Marcela, Gárate Valentina, Rodríguez-Siza Jose, Tello Samantha, Bustamante Marco, Armisen Ricardo, Matthies Douglas J, Zapata-Torres Gerald, González-Hormazabal Patricio, Molina María Carmen

Abstract excerpt

Gastric cancer (GC) is the fifth most prevalent type of cancer worldwide. Gastric tumor cells express MICA protein, a ligand to NKG2D receptor that triggers natural killer (NK) cells effector functions for early tumor elimination. MICA gene is highly polymorphic, thus originating alleles that encode protein variants with a controversial role in cancer. The main goal of this work was to study MICA gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33868281
DOI: 10.3389/fimmu.2021.645528
PMCID: PMC8045969

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