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Alteration of Mitochondrial Integrity as Upstream Event in the Pathophysiology of SOD1-ALS

6 Apr 2022

Abstract excerpt

Little is known about the early pathogenic events by which mutant superoxide dismutase 1 (SOD1) causes amyotrophic lateral sclerosis (ALS). This lack of mechanistic understanding is a major barrier to the development and evaluation of efficient therapies. Although protein aggregation is known to be involved, it is not understood how mutant SOD1 causes degeneration of motoneurons (MNs). Previous research has...

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PMID: 35406813
DOI: 10.3390/cells11071246

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