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Article

ER Stress and UPR in Familial Amyotrophic Lateral Sclerosis

1 Feb 2006

Abstract excerpt

The primary mechanism by which mutations in Cu, Zn-superoxide dismutase (SOD1) contribute to progressive motor neuron loss in familial amyotrophic lateral sclerosis (FALS) remains unknown. Misfolded protein aggregates, ubiquitin-proteasome system impairment and neuronal apoptosis mediated by death receptor or mitochondrial-dependent pathways are implicated in mutant SOD1-induced toxicity. Recent evidence from...

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PMID: 16472115
DOI: 10.2174/156652406775574550

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