Article
Structurally designed attenuated subunit vaccines for S. aureus LukS-PV and LukF-PV confer protection in a mouse bacteremia model.
PloS one - 1 Jan 2013
Karauzum Hatice, Adhikari Rajan P, Sarwar Jawad, Devi V Sathya, Abaandou Laura, Haudenschild Christian, Mahmoudieh Mahta, Boroun Atefeh R, Vu Hong, Nguyen Tam, Warfield Kelly L, Shulenin Sergey, Aman M Javad
Abstract excerpt
Previous efforts towards S. aureus vaccine development have largely focused on cell surface antigens to induce opsonophagocytic killing aimed at providing sterile immunity, a concept successfully applied to other Gram-positive pathogens such as Streptococcus pneumoniae. However, these approaches have largely failed, possibly in part due to the remarkable diversity of the staphylococcal virulence factors such as...
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