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Staphylococcus aureus Panton-Valentine Leukocidin worsens acute implant-associated osteomyelitis in humanized BRGSF mice

3 Jan 2024

Abstract excerpt

Abstract Staphylococcus aureus is the most common pathogen that causes implant-associated osteomyelitis, a clinically incurable disease. Immune evasion of S. aureus relies on various mechanisms to survive within the bone niche, including the secretion of leukotoxins such as Panton-Valentine leukocidin (PVL). PVL is a pore-forming toxin exhibiting selective human tropism for C5a receptors (C5aR1 and C5aR2) and...

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PMID: 38505530
DOI: 10.1093/jbmrpl/ziad005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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