Article
A histidine-to-arginine substitution in Panton-Valentine leukocidin from USA300 community-acquired methicillin-resistant Staphylococcus aureus does not impair its leukotoxicity.
Infection and immunity - 1 Jan 2010
Besseyre des Horts Timothée, Dumitrescu Oana, Badiou Cédric, Thomas Damien, Benito Yvonne, Etienne Jerome, Vandenesch François, Lina Gerard
Abstract excerpt
Panton-Valentine leukocidin (PVL) is a synergohymenotropic toxin (SHT) produced by Staphylococcus aureus. At present, there are conflicting reports on the leukotoxic activity of PVL and its consequent role as a virulence factor in USA300. In this work, we compared the cytolytic effects induced by wild-type PVL and those of PVL harboring a histidine-to-arginine substitution at amino acid 176 in the S. aureus...
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