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Article

Assembly of the Bi-component leukocidin pore examined by truncation mutagenesis.

The Journal of biological chemistry - 27 Jan 2006

Miles George, Jayasinghe Lakmal, Bayley Hagan

Abstract excerpt

Staphylococcal leukocidin (Luk) and alpha-hemolysin (alphaHL) are members of the same family of beta barrel pore-forming toxins (betaPFTs). Although the alphaHL pore is a homoheptamer, the Luk pore is formed by the co-assembly of four copies each of the two distantly related polypeptides, LukF and LukS, to form an octamer. Here, we examine N- and C-terminal truncation mutants of LukF and LukS. LukF subunits...

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Identifiers

PMID: 16269405
DOI: 10.1074/jbc.M510842200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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