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Staphylococcus aureus Panton-Valentine Leukocidin Causes Necrotizing Pneumonia

18 Jan 2007

Abstract excerpt

The Staphylococcus aureus Panton-Valentine leukocidin (PVL) is a pore-forming toxin secreted by strains epidemiologically associated with the current outbreak of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) and with the often-lethal necrotizing pneumonia. To investigate the role of PVL in pulmonary disease, we tested the pathogenicity of clinical isolates, isogenic PVL-negative and...

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PMID: 17234914
DOI: 10.1126/science.1137165

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Related research

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Staphylococcus aureus Panton-Valentine Leukocidin Causes Necrotizing PneumoniaPMID 17234914Read ↗

Is Panton‐Valentine Leukocidin the Major Virulence Determinant in Community‐Associated Methicillin‐Resistant <i>Staphylococcus aureus</i> Disease?Semantic proximity Read ↗

Augmented production of Panton-Valentine leukocidin toxin in methicillin-resistant and methicillin-susceptible Staphylococcus aureus is associated with worse outcome in a murine skin infection model.Semantic proximity Read ↗

Panton-Valentine leukocidin is not a virulence determinant in murine models of community-associated methicillin-resistant Staphylococcus aureus disease.Semantic proximity Read ↗

Contribution of Panton-Valentine Leukocidin in Community-Associated Methicillin-Resistant Staphylococcus aureus PathogenesisSemantic proximity Read ↗

Necrotizing pneumonia due to clonally diverse Staphylococcus aureus strains producing Panton-Valentine leukocidin: the Czech experience.Semantic proximity Read ↗

Studying Staphylococcal Leukocidins: A Challenging EndeavorSemantic proximity Read ↗

Differential Distribution and Expression of Panton-Valentine Leucocidin among Community-Acquired Methicillin-Resistant Staphylococcus aureus StrainsSemantic proximity Read ↗

The first case of fatal pneumonia caused by Panton-Valentine leukocidin-producing Staphylococcus aureus in an infant in the Czech Republic.Semantic proximity Read ↗

Panton-Valentine Leukocidin Facilitates the Escape of Staphylococcus aureus From Human Keratinocyte Endosomes and Induces ApoptosisSemantic proximity Read ↗

Identification of a Novel Staphylococcus aureus Two-Component Leukotoxin Using Cell Surface ProteomicsSemantic proximity Read ↗

Presence of genes encoding panton-valentine leukocidin is not the primary determinant of outcome in patients with hospital-acquired pneumonia due to Staphylococcus aureus.Semantic proximity Read ↗

The genes for Panton Valentine leukocidin (PVL) are conserved in diverse lines of methicillin-resistant and methicillin-susceptible Staphylococcus aureus.Semantic proximity Read ↗

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