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Article

Imputing amino acid polymorphisms in human leukocyte antigens.

PloS one - 1 Jan 2013

Jia Xiaoming, Han Buhm, Onengut-Gumuscu Suna, Chen Wei-Min, Concannon Patrick J, Rich Stephen S, Raychaudhuri Soumya, de Bakker Paul I W

Abstract excerpt

DNA sequence variation within human leukocyte antigen (HLA) genes mediate susceptibility to a wide range of human diseases. The complex genetic structure of the major histocompatibility complex (MHC) makes it difficult, however, to collect genotyping data in large cohorts. Long-range linkage disequilibrium between HLA loci and SNP markers across the major histocompatibility complex (MHC) region offers an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23762245
DOI: 10.1371/journal.pone.0064683
PMCID: PMC3675122

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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