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Antigenicity of tissues and organs from GGTA1/CMAH/β4GalNT2 triple gene knockout pigs

27 Jun 2018

Abstract excerpt

Clinical xenotransplantations have been hampered by human preformed antibody-mediated damage of the xenografts. To overcome biological incompatibility between pigs and humans, one strategy is to remove the major antigens [Gal, Neu5Gc, and Sd(a)] present on pig cells and tissues. Triple gene (GGTA1, CMAH, and β 4GalNT2) knockout (TKO) pigs were produced in our laboratory by CRISPR-Cas9 targeting. To investigate...

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PMID: 30007952
DOI: 10.7555/jbr.32.20180018

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