Article
Next-generation genotype imputation service and methods.
Nature genetics - 1 Oct 2016
Das Sayantan, Forer Lukas, Schönherr Sebastian, Sidore Carlo, Locke Adam E, Kwong Alan, Vrieze Scott I, Chew Emily Y, Levy Shawn, McGue Matt, Schlessinger David, Stambolian Dwight, Loh Po-Ru, Iacono William G, Swaroop Anand, Scott Laura J, Cucca Francesco, Kronenberg Florian, Boehnke Michael, Abecasis Gonçalo R, Fuchsberger Christian
Abstract excerpt
Genotype imputation is a key component of genetic association studies, where it increases power, facilitates meta-analysis, and aids interpretation of signals. Genotype imputation is computationally demanding and, with current tools, typically requires access to a high-performance computing cluster and to a reference panel of sequenced genomes. Here we describe improvements to imputation machinery that reduce...
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