Article
Reduced expression of insulin-like growth factor 1 receptor leads to accelerated intervertebral disc degeneration in mice.
International journal of immunopathology and pharmacology - 1 Jan 2000
Li B, Zheng X-F, Ni B-B, Yang Y-H, Jiang S-D, Lu H, Jiang L-S
Abstract excerpt
Insulin-like growth factor 1 (IGF-1) and its receptor (insulin-like growth factor 1 receptor, IGF1R) can regulate the extracellular matrix synthesis and play a crucial role in maintaining the normal functions of the intervertebral disc (IVD). The objective of this study was to investigate whether there would be accelerated IVD degeneration (IVDD) in IGF1R+/- mice. Three IGF1R+/- male mice and three wild-type male...
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