Article
The skeletal phenotype of chondroadherin deficient mice.
PloS one - 1 Jan 2014
Hessle Lovisa, Stordalen Gunhild A, Wenglén Christina, Petzold Christiane, Tanner Elizabeth K, Brorson Sverre-Henning, Baekkevold Espen S, Önnerfjord Patrik, Reinholt Finn P, Heinegård Dick
Abstract excerpt
Chondroadherin, a leucine rich repeat extracellular matrix protein with functions in cell to matrix interactions, binds cells via their α2β1 integrin as well as via cell surface proteoglycans, providing for different sets of signals to the cell. Additionally, the protein acts as an anchor to the matrix by binding tightly to collagens type I and II as well as type VI. We generated mice with inactivated...
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